Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations
Identifieur interne : 000356 ( Main/Exploration ); précédent : 000355; suivant : 000357Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations
Auteurs : Haiyan Lei ; Tianwei Li ; Bingjie Li ; Shien Tsai ; Robert J. Biggar ; Francis Nkrumah [Ghana] ; Janet Neequaye [Ghana] ; Marina Gutierrez [Argentine] ; Sidnei Epelman [Brésil] ; Sam M. Mbulaiteye ; Kishor Bhatia ; Shyh-Ching LoSource :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
Epstein Barr virus (EBV) sequence variation is thought to contribute to Burkitt lymphoma (BL), but lack of data from primary BL tumors hampers efforts to test this hypothesis. We directly sequenced EBV from 12 BL biopsies from Ghana, Brazil, and Argentina, aligned the obtained reads to the wild-type (WT) EBV reference sequence, and compared them with 100 published EBV genomes from normal and diseased people from around the world. The 12 BL EBVs were Type 1. Eleven clustered close to each other and to EBV from Raji BL cell line, but away from 12 EBVs reported from other BL-derived cell lines and away from EBV from NPC and healthy people from Asia. We discovered 23 shared novel nucleotide-base changes in the latent membrane protein (LMP)-1 promoter and gene (associated with 9 novel amino acid changes in the LMP-1 protein) of the 11 BL EBVs. Alignment of this region for the 112 EBV genomes revealed four distinct patterns, tentatively termed patterns A to D. The distribution of BL EBVs was 48%, 8%, 24% and 20% for patterns A to D, respectively; the NPC EBV’s were Pattern B, and EBV-WT was pattern D. Further work is needed to investigate the association between EBV LMP-1 patterns with BL.
Url:
DOI: 10.1038/srep16706
PubMed: 26593963
PubMed Central: 4655394
Affiliations:
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Biggar</name><affiliation><nlm:aff id="a2"><institution>Bethesda Maryland</institution>, formerly<country>NCI</country></nlm:aff><wicri:noCountry code="nlm country">NCI</wicri:noCountry></affiliation></author><author><name sortKey="Nkrumah, Francis" sort="Nkrumah, Francis" uniqKey="Nkrumah F" first="Francis" last="Nkrumah">Francis Nkrumah</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Noguchi Memorial Institute</institution>, Accra,<country>Ghana</country></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neequaye, Janet" sort="Neequaye, Janet" uniqKey="Neequaye J" first="Janet" last="Neequaye">Janet Neequaye</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Child Health, University of Ghana</institution>, Accra,<country>Ghana</country></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gutierrez, Marina" sort="Gutierrez, Marina" uniqKey="Gutierrez M" first="Marina" last="Gutierrez">Marina Gutierrez</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Laboratorio Stamboulian, Buenos Aires</institution>,<country>Argentina</country></nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Epelman, Sidnei" sort="Epelman, Sidnei" uniqKey="Epelman S" first="Sidnei" last="Epelman">Sidnei Epelman</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Pediatric Oncology, St Marcelina Hospital</institution>, Sao Paolo,<country>Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mbulaiteye, Sam M" sort="Mbulaiteye, Sam M" uniqKey="Mbulaiteye S" first="Sam M." last="Mbulaiteye">Sam M. Mbulaiteye</name><affiliation><nlm:aff id="a7"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville,<country>Maryland</country></nlm:aff><wicri:noCountry code="nlm country">Maryland</wicri:noCountry></affiliation></author><author><name sortKey="Bhatia, Kishor" sort="Bhatia, Kishor" uniqKey="Bhatia K" first="Kishor" last="Bhatia">Kishor Bhatia</name><affiliation><nlm:aff id="a7"><institution>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</institution>, Rockville,<country>Maryland</country></nlm:aff><wicri:noCountry code="nlm country">Maryland</wicri:noCountry></affiliation></author><author><name sortKey="Lo, Shyh Ching" sort="Lo, Shyh Ching" uniqKey="Lo S" first="Shyh-Ching" last="Lo">Shyh-Ching Lo</name><affiliation><nlm:aff id="a1"><institution>Center for Biologics Evaluation and Research, Food and Drug Administration</institution>, Silver Spring,<country>Maryland</country></nlm:aff><wicri:noCountry code="nlm country">Maryland</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Epstein Barr virus (EBV) sequence variation is thought to contribute to Burkitt lymphoma (BL), but lack of data from primary BL tumors hampers efforts to test this hypothesis. We directly sequenced EBV from 12 BL biopsies from Ghana, Brazil, and Argentina, aligned the obtained reads to the wild-type (WT) EBV reference sequence, and compared them with 100 published EBV genomes from normal and diseased people from around the world. The 12 BL EBVs were Type 1. Eleven clustered close to each other and to EBV from Raji BL cell line, but away from 12 EBVs reported from other BL-derived cell lines and away from EBV from NPC and healthy people from Asia. We discovered 23 shared novel nucleotide-base changes in the latent membrane protein (LMP)-1 promoter and gene (associated with 9 novel amino acid changes in the LMP-1 protein) of the 11 BL EBVs. Alignment of this region for the 112 EBV genomes revealed four distinct patterns, tentatively termed patterns A to D. The distribution of BL EBVs was 48%, 8%, 24% and 20% for patterns A to D, respectively; the NPC EBV’s were Pattern B, and EBV-WT was pattern D. Further work is needed to investigate the association between EBV LMP-1 patterns with BL.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Epstein, M A" uniqKey="Epstein M">M. A. Epstein</name></author><author><name sortKey="Achong, B G" uniqKey="Achong B">B. G. Achong</name></author><author><name sortKey="Barr, Y M" uniqKey="Barr Y">Y. M. Barr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hjalgrim, H" uniqKey="Hjalgrim H">H. Hjalgrim</name></author><author><name sortKey="Engels, E A" uniqKey="Engels E">E. A. Engels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harabuchi, Y" uniqKey="Harabuchi Y">Y. Harabuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De The, G" uniqKey="De The G">G. de The</name></author><author><name sortKey="Ablashi, D V" uniqKey="Ablashi D">D. V. 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Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansson, A" uniqKey="Jansson A">A. Jansson</name></author><author><name sortKey="Johansson, P" uniqKey="Johansson P">P. Johansson</name></author><author><name sortKey="Li, S" uniqKey="Li S">S. Li</name></author><author><name sortKey="Rymo, L" uniqKey="Rymo L">L. Rymo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Busson, P" uniqKey="Busson P">P. Busson</name></author><author><name sortKey="Edwards, R H" uniqKey="Edwards R">R. H. Edwards</name></author><author><name sortKey="Tursz, T" uniqKey="Tursz T">T. Tursz</name></author><author><name sortKey="Raab Traub, N" uniqKey="Raab Traub N">N. Raab-Traub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walling, D M" uniqKey="Walling D">D. M. Walling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nkrumah, F" uniqKey="Nkrumah F">F. Nkrumah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nkrumah, F K" uniqKey="Nkrumah F">F. K. Nkrumah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gutierrez, M I" uniqKey="Gutierrez M">M. I. Gutierrez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K. Tamura</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Argentine</li><li>Brésil</li><li>Ghana</li></country></list><tree><noCountry><name sortKey="Bhatia, Kishor" sort="Bhatia, Kishor" uniqKey="Bhatia K" first="Kishor" last="Bhatia">Kishor Bhatia</name><name sortKey="Biggar, Robert J" sort="Biggar, Robert J" uniqKey="Biggar R" first="Robert J." last="Biggar">Robert J. Biggar</name><name sortKey="Lei, Haiyan" sort="Lei, Haiyan" uniqKey="Lei H" first="Haiyan" last="Lei">Haiyan Lei</name><name sortKey="Li, Bingjie" sort="Li, Bingjie" uniqKey="Li B" first="Bingjie" last="Li">Bingjie Li</name><name sortKey="Li, Tianwei" sort="Li, Tianwei" uniqKey="Li T" first="Tianwei" last="Li">Tianwei Li</name><name sortKey="Lo, Shyh Ching" sort="Lo, Shyh Ching" uniqKey="Lo S" first="Shyh-Ching" last="Lo">Shyh-Ching Lo</name><name sortKey="Mbulaiteye, Sam M" sort="Mbulaiteye, Sam M" uniqKey="Mbulaiteye S" first="Sam M." last="Mbulaiteye">Sam M. Mbulaiteye</name><name sortKey="Tsai, Shien" sort="Tsai, Shien" uniqKey="Tsai S" first="Shien" last="Tsai">Shien Tsai</name></noCountry><country name="Ghana"><noRegion><name sortKey="Nkrumah, Francis" sort="Nkrumah, Francis" uniqKey="Nkrumah F" first="Francis" last="Nkrumah">Francis Nkrumah</name></noRegion><name sortKey="Neequaye, Janet" sort="Neequaye, Janet" uniqKey="Neequaye J" first="Janet" last="Neequaye">Janet Neequaye</name></country><country name="Argentine"><noRegion><name sortKey="Gutierrez, Marina" sort="Gutierrez, Marina" uniqKey="Gutierrez M" first="Marina" last="Gutierrez">Marina Gutierrez</name></noRegion></country><country name="Brésil"><noRegion><name sortKey="Epelman, Sidnei" sort="Epelman, Sidnei" uniqKey="Epelman S" first="Sidnei" last="Epelman">Sidnei Epelman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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